HPU / KPU | A metabolic disorder with fatal consequences for the organism

HPU / KPU (hemopyrrollactamuria) is one of the most common metabolic disorders, but also one of the most ignored diseases of the local orthodox medicine. But also naturopaths unfortunately are very rarely versed in terms of HPU / KPU.

Since the so-called pyrrolics suffer from severe multi-organ complaints and also mental difficulties, they are usually permanent guests at various doctors and psychologists, however, where usually are  treated individual symptoms only and the metabolic disease progresses more and more.

The agonies of the patients are absolutely unnecessary, as a clever diagnosis is very easy to grasp and the treatment is very simple. Assuming that you have found a doctor who is a little savvy on the subject.

What exactly is a hemopyrrollactamuria?

HPU / KPU is a biochemical disorder in the synthesis of the red blood pigment (hemoglobin), which is usually genetic or acquired. HPU / KPU is a common cause of a variety of medical conditions in which the doctor does not find the origin.

In hemopyrrollactamuria, there are problems with the synthesis of the red blood pigment hemoglobin. This results in various problems.

The formation of heme is severely disturbed, which plays a crucial role in the energy metabolism and  especially is needed for detoxification. In addition, heme is responsible for the oxygen supply of the muscles.

In addition, a kind of harmful heme is produced, which can not easily leave the body, as due to the HPU / KPU, the detoxification of this substance is hindered. In this case, the body uses a trick and binds vitamin B6, zinc and manganese to the wrong heme, which can be excreted through the urine.

In this way, the body gets rid of the pollutants, but at the same time loses essential vitamins, which are needed for more than one hundred metabolic processes in the body.

But a Pyrolic is not able to compensate the loss of vitamins with the food, so the problem is usually not recognized and the situation can only become more difficult over time. In this way, more and more complaints arise and at mostly only the symptoms are treated, but the patient is still getting sicker.

The HPU / KPU often has a genetic cause and is inherited. If the parents have a thyroid disorder or mental health problems, as a descendant with health problems you should always think of the HPU / KPU.

But you can also acquire this disease in the course of life. Currently two causes are being discussed. First, Dr. Bodo Kulinski reports that cervical vertebrae can trigger the HPU / KPU. On the other hand, there is also much evidence that heavy metal pollution may be responsible for this disorder.

What does HPU / KPU mean for health?

One of the most important functions in the human body is the constant detoxification. Everyday we absorb considerable amounts of pollutants via the air, food, medicines or luxury foods. These pollutants must leave the body immediately, otherwise there would be diseases and health restrictions. A healthy body can accomplish this task, but unfortunately at pyrrolics it is quite different. The excreted vitamins and minerals vitamin B6, zinc and manganese are essential for a body’s detoxification.

A deficiency of these lost nutrients is noticeable from a certain amount and becomes a serious and devastating problem for the body. Many metabolic processes become weaker over time and also the body’s own detoxification collapses. More and more pollutants accumulate in the tissue and the organs, which in the long run causes enormous damage to the body. In this way more and more symptoms and health problems arise.

Especially when heavy metals come into play. These anyway can be detoxified by the body very badly, but at Pyrrolics they are stored in the tissue and do their mischief there. Mostly with fatal consequences, because in addition to the mentioned problems now many essential enzymes are blocked, too, whereby still more metabolism and detoxification process in the body can only partially or not at all proceed.

Typical HPU-KPU symptoms and complaints

  • Pale complexion
  • Various anemias (iron or B vitamins)
  • White spots under the fingernails
  • Fatigue / weakness
  • Poor memory performance – especially the short-term memory
  • Hypoglycaemia
  • Inflammation in the gastrointestinal area
  • Constipation
  • Food intolerances
  • Histamine intolerance
  • Allergies
  • Morning sickness
  • Lack of stress resistance
  • Adrenal fatigue
  • Joint pain
  • Muscle pain
  • Mental discomfort, depression, schizophrenia, anxiety, restlessness
  • Low blood pressure and pulse
  • Hypersensitivity to sunlight
  • Cardiovascular disease (increased homocysteine)
  • In young age: increased mobility of the joints (hypermobility)
  • In old age it is the opposite: The joints become immobile and stiff
  • Blood sugar problems: fructose intolerance and diabetes Type 2
  • Insomnia
  • Loss of appetite

In addition, the HPU / KPU contributes to further illness, triggers or exacerbates them:

  • Adrenal fatigue
  • Hashimoto thyroiditis
  • Other thyroid disease (underactive or overactive)
  • PBC (autoimmune disease of the liver)
  • Type 2 diabetes
  • ADD / ADHD
  • Autism
  • Strengthening of addiction to various substances
  • Migraine
  • Bipolar psychosis, panic disorders, depression
  • Mitochondriopathies

HPU / KPU – Diagnostics and Therapeutic options

For a long time only the classical kryptopyrrole test (KPU) was available, which is very inaccurate and does not make it possible to detect specific metabolic disturbance. Instead, only pyrrole compounds in the urine are measured.

Since 2000, the original HPU® test is available, which is much more accurate now and capable of measuring specific HPL complexes, formed in the form of HPU only. Because of this, it should also be clear that HPU is not equal to KPU, although both diseases are often presented as one disease with two names.

The original HPU® test has two variants. There is the cheaper option, in which only the morning urine is examined. This one is chosen, if complaints exist since a short time, and also for children this test variant is sufficient.

If the symptoms have been around for some time and the person is chronically ill,  you should choose the 24-hour urine test, as this is more accurate and also covers the so-called evening excretors. Many patients who have had HPU / KPU for a long time, often shed HPL complexes for 1-2 hours after meals or overnight. Therefore, the simple morning urine test in such a case could be false negative.

How is HPU / KPU treated?

Actually, very simple. And only with micronutrients, minerals and trace elements. The excreted and missing body micronutrients must be administered orally.

According to Dr. Kamsteeg many HPU sufferers have problems to activate vitamin B6, so it is advisable to directly replace the activated form of vitamin B6 in the form of P-5-P. The amount in adults is about 50-100mg / day. But the need may vary from patient to patient. However, a daily dose of 2000mg should not be exceeded.

In addition, zinc must be replaced. In which form is a question of faith and everyone prefers another form. Dr. Kamsteeg recommends zinc gluconate, others prefer zinc citrate. Personally, I am convinced about zinc orotate. So everyone should decide for themselves. For zinc, the recommended daily dose is 30-60mg. But there are patients also who need 125mg and more.

And when zinc is added, manganese should not be added, too. Here a daily dose of 10-20mg is recommended. Meanwhile, there are various providers that offer so-called combination products with the micronutrients i mentioned above.

Dr. Kamsteeg offers different variants of his Depyrrol, Heidelberger Chlorella has the B-LIFE Protect, and Monapur the Kryptosan. But since it is often recommended to take the zinc twice a day, as well as the manganese, such a splitting with combined preparations is difficult to handle, so I personally use all three micronutrients separately.

In addition to these three important micronutrients, pyrrolics always should carefully keep an eye on the lack of other micronutrients, to compensate in time, as there are often deficiencies, too. Especially since the intestine often is damaged due to intolerances and thus can not absorb enough micronutrients.

Dosage Tips

It is not important how high the result of the HPU test is and you can not determine the dosage of the micronutrients by the test result.

There are some patients who have very high levels of HPL, but have only little discomfort and need low doses of micronutrients. On the other hand, there are patients who have low HPL levels, have massive discomfort and also need to take quite high-doses of micronutrients.

But in the end, every patient has to find the right dosage for himself. It is ideal when manganese and zinc are split into two doses. One serving in the morning for P5P and the second dose in the evening.

P5P (active vitamin B6)

In the beginning you always should increase P5P very carefully, as it can lead to a variety of side effects. It can cause severe nausea, fatigue can be significantly increased, but also mental symptoms can flare up. The fact that the metabolism starts up again and the detoxification gets going again, it may be that poisoning phenomena appear and possibly heavy metals are mobilized.

Thus you should start with a low dose (12.5mg) and then gently increase every few days or weeks. A good marker to look for, in terms of dosage, is the dream reminder. If you can remember your dreams well, you are close to the ideal dose. Most of the time the P5P dose levels off between 50-100mg. But also, there are patients who need much more.


The zinc dosage is a dividing factor  and you can find various different informations on the Internet. It is often recommended to take between 30-50mg. Kamsteeg writes in his book “HPU … and then?” That 30mg each morning and evening would be a good start. So you have to look for yourself, where the journey leads to, but also start low. 12.5mg is a good start and can be increased after 2-3 weeks.

Since zinc displaces mercury and copper in the body, poisoning can occur here, too, if the dosage is too high. But also the zinc compound that is used is important. Zinc also is available as orotate, citrate, aspartate, gluconate, etc. Mostly, the gluconate is recommended, but I personally prefer the orotate. Again, you have to try and see what is the best for you personally.


Since manganese also is lost in HPU, it must be substituted, too. The more zinc you take, the more manganese you need to take.

It should not be more than 5mg in the beginning. In the later course you can also increase the dose up to 20mg. Since manganese displaces copper, poisoning also can occur here if the dose is too high. Manganese should always be taken with a time delay to the zinc intake, as it inhibits the absorption of zinc.

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